The Malvern NanoSight LM10-HS is a unique instrument employing nanoparticle tracking analysis to characterize particle size distributions.


The NanoSight uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.


Wavelength:405nm (violet)

Camera:CCD or sCMOS

Fluorescence:Manual push/pull filter holder with 2 filters

Dimensions (W, D, H):420mm x 200mm x 260mm

Particle size:20nm* to 2000nm

Concentration range:106 to 109 particles/mL

*Provided that the particles are metal-based or have metal cores. For biological samples such as exosomes, lyposomes, micelles, etc., the limit of detection is usually above 40nm.

For more information about NTA, please visit here.

NU Core ID: NanoSight