Instruments

Spectroscopy

  • UV/Vis/NIR Spectrophotometer

    The Perkin Elmer LAMBDA 1050 is a high performance UV/Vis/NIR double beam, double monochromator, ratio-recording spectrophotometer. A 150 mm integrating sphere accessory allows diffuse reflectance and transmission measurements.

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  • Circular Dichroism Spectrophotometer

    Our state of the art Jasco J-815 CD instrument allows the simultaneous acquisition of fluorescence and CD data. Such experiments are particularly useful in assessing the extent to which protein unfolding and folding transitions are two-state in character.

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  • Fluorescence Plate Reader

     

    The Molecular Devices Gemini EM Fluorescence/Chemiluminescence Plate Reader complements the facility’s fluorimeters PC1¬† and K2 by accommodating high throughput fluorescence experiments.

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  • Fluorescence Polarization

    The PanVera (Invitrogen) Beacon 2000 Variable Temperature Fluorescence Polarization System provides a simple, rapid, and highly sensitive way to study equilibrium binding for a range of biomolecules. It measures binding affinities directly in solution and can be used to study protein-protein, protein-DNA, or receptor-ligand binding and interactions.

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  • Photon-Counting Fluorescence Spectrometer

    The ISS PC1 spectrofluorimeter is a workstation for a wide variety of highly sensitive fluorescence studies. The PC1 has excitation/emission monochromators and optional  polarizers suitable for fluorescence polarization/anisotropy and ratio measurements using both T- and L- configuration.

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  • UV/Vis DAD Spectrophotometer

    The HP (Agilent) 8452 diode array spectrophotometer is a basic analytical instrument for measuring UV/Vis spectra of solution samples in seconds.

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  • NanoDrop 3300 Fluorimeter

    The Thermo Scientific NanoDrop 3300 fluorimeter acquires full range visible emission spectra from micro-volume samples in seconds.

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  • NanoDrop Spectrophotometer

    The Thermo Scientific NanoDroop 2000c acquires full range UV/Vis absorbance spectra from micro-volume or cuvette samples in seconds.

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Analytical

  • Differential Scanning Calorimeter

    The MicroCal (GE Healthcare) differential scanning calorimeter directly measures the enthalpy of a solution as a function of temperature.

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  • Isothermal Titration Calorimeter

    The MicroCal (GE Healthcare) ITC200 isothermal titration calorimeter is a powerful tool for label-free analysis of macromolecular interactions in solution.

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  • Analytical HPLC

    This Agilent 1100 series high pressure liquid chromatography system is equipped for high sensitivity sample analysis.

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  • SEC-MALS-QELS

    The SEC-MALS-QELS system is composed of an Agilent 1260 series HPLC for size exclusion chromatography followed by a Wyatt DAWN HELEOS II multi-angle static light scattering detector, a Wyatt QELS dynamic light scattering detector, and a Wyatt T-rEx differential refractive index detector.

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  • Dynamic Light Scattering

    This batch mode DLS features a Brookhaven BI-200 goniometer and BI-9000 high speed correlator and a 3 watt argon-ion laser operating at 514 nm.

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  • Surface Plasmon Resonance

    The Reichert SR7500DC is a dual channel surface plasmon resonance spectrometer for label-free measurement of macromolecular association and dissociation.

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  • NanoSight

    The NanoSight LM10-HS is a unique instrument employing nanoparticle tracking analysis to characterize particle size distributions.

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  • BLItz Bio-layer Interferometer

    The BLItz is a micro volume instrument for characterizing the kinetics of macromolecular interactions using bio-layer interferometry with low cost disposable sensor probes. The instrument is located in the Ward building on the Chicago campus.

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Other

  • Chemiluminescence & IR Imager

    The Syngene PXi system offers fully automated capture and comprehensive analysis of chemiluminescent and fluorescent blots and gels.

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  • LAS 4010 Gel Imaging System

    The GE Healthcare ImageQuant LAS 4010 gel imaging system allows visualization, imaging and quantitative measurements of macromolecules in stained gels.

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  • Phosphorimager

    The Molecular Dynamics (GE Healthcare) Storm 860 phosphoimager images storage phosphor screens after exposure to radioisotope-labeled samples or electron scattering.

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  • Fluorimager

    The GE Healthcare Typhoon 9400 allows sensitive detection and quantitation of fluorescent macromolecules in gel sandwiches, agarose and polyacrylamide gels, membranes, and microplates.

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  • Real Time PCR

    The Bio-Rad iCycler collects and reports PCR amplification and denaturation data in real-time.

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